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La Metformina: il farmaco per il diabete che allunga la vita



Metformin inhibits melanoma development through autophagy and apoptosis mechanisms. Tomic T, et al., Cell Death Dis. 2011 Sep

Is metformin poised for a second career as an antimicrobial?Malik F, et al., Diabetes Metab Res Rev. 2018;e2975. DOI:10.1002/dmrr.2975

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH. Cochrane Database Syst Rev. 2009 Oct

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing.Prattichizzo F, et.al,  Ageing Res Rev. 2018 Dec

Effect of Metformin on Different Non-Diabetes Related Conditions, a Special Focus on Malignant Conditions: Review of Literature.Abdelgadir E, Ali R, Rashid F, Bashier A., J Clin Med Res. 2017 May

Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis. Campbell JM, Bellman SM, Stephenson MD, Lisy K.
Ageing Res Rev. 2017 Nov

Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction.Varjabedian L,  et al., Am J Cardiovasc Drugs. 2018 Feb

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease. Hardie DG. J Int Med. 2014

O’Neill HM et al. AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity. O’Neill HM et al., Mol Cell Endoctinol. 2013

AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in ObesityLuo T, et. al., Diabetes. 2016 Aug

Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomizeddouble-blindedplacebo-controlled cross-over trialTrolle B, et al., Hum Reprod. 2007 Nov

Metformin for treatment of antipsychotic-induced weight gain: a randomized, placebo-controlled study.Wang M, et al., Schizophr Res. 2012 Jun;

Long-term treatment with metformin in obeseinsulin-resistant adolescentsresults of a randomized double-blinded placebo-controlled trial.van der Aa MP, et al., Nutr Diabetes. 2016 Aug;

Metformin extended release treatment of adolescent obesity: a 48-week randomizeddouble-blindplacebo-controlled trial with 48-week follow-up.Wilson DM, et al., Arch Pediatr Adolesc Med. 2010 Feb

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study. Koenig AM,  et al., Alzheimer Dis Assoc Disord. 2017 Apr-Jun

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice.Patil SP, et al.,  Neuroscience. 2014 Sep

Metformin – a Future Therapy for Neurodegenerative Diseases : Theme: Drug Discovery, Development and Delivery in Alzheimer‘s Disease Guest Editor: Davide Brambilla. Markowicz-Piasecka M, et al., Pharm Res. 2017 Dec

Metformin for cancer and aging prevention: is it a time to make the long story short?Anisimov VN., Oncotarget. 2015 Nov

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment. Sui X,  et. al, Mol Pharm. 2015 Nov

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