La Metformina: il farmaco per il diabete che allunga la vita

By 7 gennaio 2019Gli integratori


Metformin inhibits melanoma development through autophagy and apoptosis mechanisms. Tomic T, et al., Cell Death Dis. 2011 Sep

Is metformin poised for a second career as an antimicrobial?Malik F, et al., Diabetes Metab Res Rev. 2018;e2975. DOI:10.1002/dmrr.2975

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH. Cochrane Database Syst Rev. 2009 Oct

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing.Prattichizzo F,,  Ageing Res Rev. 2018 Dec

Effect of Metformin on Different Non-Diabetes Related Conditions, a Special Focus on Malignant Conditions: Review of Literature.Abdelgadir E, Ali R, Rashid F, Bashier A., J Clin Med Res. 2017 May

Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis. Campbell JM, Bellman SM, Stephenson MD, Lisy K.
Ageing Res Rev. 2017 Nov

Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction.Varjabedian L,  et al., Am J Cardiovasc Drugs. 2018 Feb

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease. Hardie DG. J Int Med. 2014

O’Neill HM et al. AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity. O’Neill HM et al., Mol Cell Endoctinol. 2013

Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomizeddouble-blindedplacebo-controlled cross-over trialTrolle B, et al., Hum Reprod. 2007 Nov

Metformin for treatment of antipsychotic-induced weight gain: a randomized, placebo-controlled study.Wang M, et al., Schizophr Res. 2012 Jun;

Long-term treatment with metformin in obeseinsulin-resistant adolescentsresults of a randomized double-blinded placebo-controlled trial.van der Aa MP, et al., Nutr Diabetes. 2016 Aug;

Metformin extended release treatment of adolescent obesity: a 48-week randomizeddouble-blindplacebo-controlled trial with 48-week follow-up.Wilson DM, et al., Arch Pediatr Adolesc Med. 2010 Feb

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study. Koenig AM,  et al., Alzheimer Dis Assoc Disord. 2017 Apr-Jun

Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice.Patil SP, et al.,  Neuroscience. 2014 Sep

Join the discussion 6 Comments

  • silvia ha detto:

    Ciao Michela, grazie per l’ articolo molto interessante. Sei sempre super avanti 🙂 Questo farmaco va assunto con continuità tutto l’anno o va preso a cicli?

  • Bianca ha detto:

    interessante, ma si tratta pur sempre di un farmaco…

  • Luigi ha detto:

    Articolo veramente interessante e completo in tutti i dettagli, complimenti !

    • Faceboost ha detto:

      Grazie Luigi. Mi fa piacere che ti sia piaciuto. Era tanto che volevo scrivere questo articolo su questa molecola molto interessante. Alla fine ho raccolto un bel pò di materiale e ce l’ho fatta. A presto.

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